This change allows LytA to associate with and degrade its cell

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However, penicillin treatment or prolonged stationary phase growth triggers the degradation of a key LTA synthase, causing a switch to the production of wall anchored TAs (WTAs). This change allows LytA to associate with and degrade its cell wall substrate, thus promoting osmotic lysis. Lysis in response to these drugs requires the activity of cell wall hydrolases called autolysins, but how penicillins misactivate these deadly enzymes has long remained unclear.

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